Physicochemical optimisation of plasmid delivery by cationic lipids
Identifieur interne : 001F70 ( Main/Exploration ); précédent : 001F69; suivant : 001F71Physicochemical optimisation of plasmid delivery by cationic lipids
Auteurs : Isabelle Tranchant [France] ; Betty Thompson [France] ; Céline Nicolazzi [France] ; Nathalie Mignet [France] ; Daniel Scherman [France]Source :
- The Journal of Gene Medicine [ 1099-498X ] ; 2004-02.
English descriptors
- Teeft :
- Acta, Amine, Amino acids, Biochim, Biochim biophys acta, Bioconjug chem, Biophys, Cationic, Cationic charges, Cationic complexes, Cationic gene transfer, Cationic lipid, Cationic lipids, Cationic lipoplexes, Cationic liposomes, Chem, Colloidal stability, Copyright, Dope, Dotap, Dotma, Ethanolic, Ethanolic injection, Ethanolic injection method, Fatty acid chains, Gene, Gene delivery, Gene therapy, Gene transfection, Gene transfer, Glucose, Headgroup, Hydration, Hydration method, Hydrocarbon chains, John wiley sons, Lipid, Lipid bilayer, Lipoplex, Lipoplexes, Lipopolyamines, Liposome, Negative charges, Nucleic acids, Optimisation, Particle size, Pegylated, Pegylated lipoplexes, Peptide, Plasmid, Plasmid delivery, Proc natl acad, Sonication, Tranchant, Transfection, Tumour, Vesicle, Vivo.
Abstract
Non‐viral gene therapy is based on the use of plasmid expression vectors and chemical or physical plasmid DNA delivery systems. This review discusses the roles of cationic lipids as vectors for gene transfection, reviews different strategies employed to improve cationic lipids for in vivo use, and provides original results on the physicochemistry of lipoplexes. Cationic lipid/DNA delivery vehicles have evolved considerably since their initial gene transfection experiments. Much work has been carried out to investigate their structure/activity relationships, methods of formulation and physicochemical properties. Further work has also focused on enhancing and prolonging their stability in a physiological environment as well as increasing their site‐specific and tissue‐specific interactions. Original data presented in this report confirm that cationic lipids associated to DNA form supramolecular lamellar structures, which protect DNA from serum DNAse degradation. The effect of formulation (and hence the size of the particles) on lipoplex in vivo circulation half‐life and biodistribution is also discussed. A list of abbreviations can be found at the end of the review. Copyright © 2004 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/jgm.509
Affiliations:
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liposomes</term><term>Chem</term><term>Colloidal stability</term><term>Copyright</term><term>Dope</term><term>Dotap</term><term>Dotma</term><term>Ethanolic</term><term>Ethanolic injection</term><term>Ethanolic injection method</term><term>Fatty acid chains</term><term>Gene</term><term>Gene delivery</term><term>Gene therapy</term><term>Gene transfection</term><term>Gene transfer</term><term>Glucose</term><term>Headgroup</term><term>Hydration</term><term>Hydration method</term><term>Hydrocarbon chains</term><term>John wiley sons</term><term>Lipid</term><term>Lipid bilayer</term><term>Lipoplex</term><term>Lipoplexes</term><term>Lipopolyamines</term><term>Liposome</term><term>Negative charges</term><term>Nucleic acids</term><term>Optimisation</term><term>Particle size</term><term>Pegylated</term><term>Pegylated lipoplexes</term><term>Peptide</term><term>Plasmid</term><term>Plasmid delivery</term><term>Proc natl acad</term><term>Sonication</term><term>Tranchant</term><term>Transfection</term><term>Tumour</term><term>Vesicle</term><term>Vivo</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non‐viral gene therapy is based on the use of plasmid expression vectors and chemical or physical plasmid DNA delivery systems. This review discusses the roles of cationic lipids as vectors for gene transfection, reviews different strategies employed to improve cationic lipids for in vivo use, and provides original results on the physicochemistry of lipoplexes. Cationic lipid/DNA delivery vehicles have evolved considerably since their initial gene transfection experiments. Much work has been carried out to investigate their structure/activity relationships, methods of formulation and physicochemical properties. Further work has also focused on enhancing and prolonging their stability in a physiological environment as well as increasing their site‐specific and tissue‐specific interactions. Original data presented in this report confirm that cationic lipids associated to DNA form supramolecular lamellar structures, which protect DNA from serum DNAse degradation. The effect of formulation (and hence the size of the particles) on lipoplex in vivo circulation half‐life and biodistribution is also discussed. A list of abbreviations can be found at the end of the review. Copyright © 2004 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Tranchant, Isabelle" sort="Tranchant, Isabelle" uniqKey="Tranchant I" first="Isabelle" last="Tranchant">Isabelle Tranchant</name></region><name sortKey="Mignet, Nathalie" sort="Mignet, Nathalie" uniqKey="Mignet N" first="Nathalie" last="Mignet">Nathalie Mignet</name><name sortKey="Mignet, Nathalie" sort="Mignet, Nathalie" uniqKey="Mignet N" first="Nathalie" last="Mignet">Nathalie Mignet</name><name sortKey="Mignet, Nathalie" sort="Mignet, Nathalie" uniqKey="Mignet N" first="Nathalie" last="Mignet">Nathalie Mignet</name><name sortKey="Nicolazzi, Celine" sort="Nicolazzi, Celine" uniqKey="Nicolazzi C" first="Céline" last="Nicolazzi">Céline Nicolazzi</name><name sortKey="Scherman, Daniel" sort="Scherman, Daniel" uniqKey="Scherman D" first="Daniel" last="Scherman">Daniel Scherman</name><name sortKey="Scherman, Daniel" sort="Scherman, Daniel" uniqKey="Scherman D" first="Daniel" last="Scherman">Daniel Scherman</name><name sortKey="Scherman, Daniel" sort="Scherman, Daniel" uniqKey="Scherman D" first="Daniel" last="Scherman">Daniel Scherman</name><name sortKey="Thompson, Betty" sort="Thompson, Betty" uniqKey="Thompson B" first="Betty" last="Thompson">Betty Thompson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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